Poly (d/l) lactide-polycaprolactone/bioactive glass nanocomposites: assessments of in vitro bioactivity and biodegradability

Authors

  • Javad Esmaeilzadeh j_es65@yahoo.com Central Research Laboratory, Esfarayen University of Technology, Esfarayen, North Khorasan, Iran
  • Saeed Hesaraki Biomaterials Group, Nanotechnology and Advanced Materials Department, Materials and Energy Research Center, Tehran, Iran
  • Shokoufeh Borhan Department of Materials and Chemical Engineering, Imam Khomeini International University- Buin Zahra Higher Education Center of Engineering and Technology, Qazvin, Iran

DOI:

https://doi.org/10.52547/jcc.3.4.1

Keywords:

In-vitro test, PDLLA/PCL, Bioactive glass nanoparticles, Bioactivity and Biodegradation

Abstract

The in vitro assessments suggested the essential features for the bio screws applications. The effects of bioactive glass nanoparticles (BG) during in vitro studies of the poly (D/L) lactide (PDLLA)/polycaprolactone (PCL)/BG nanocomposites (PPB) were assessed. The PDLLA/PCL (PP) blends were chosen as control groups. Apatite formations capabilities, weight and pH variations, alkaline phosphatase activity (ALP), and MTT assay were assigned during different immersion times up to 6 months. The XRD and SEM results revealed the superior apatite formation of PPB in simulated body fluids (SBF) compared to PP. The weight loss and pH variation results illustrated the highest values related to PP. Moreover, the MG-63 cells cultures determined the better cell viability of the PPB compared to the PP blends. Although, there are no statistically significant differences between the two groups. In addition, similar trends are shown for the ALP results where these amounts after 2 and 3 weeks incubation are considerable for PPB in comparison to PP. However, there are also no statistically significant differences between the two groups. Overall, the in vitro bioactivity and biodegradability confirmed that the PPB implants can be promised as a proper candidate for anterior cruciate ligament reconstruction screws.

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Published

2021-12-30

How to Cite

Esmaeilzadeh, J., Hesaraki, S., & Borhan, S. (2021). Poly (d/l) lactide-polycaprolactone/bioactive glass nanocomposites: assessments of in vitro bioactivity and biodegradability . Journal of Composites and Compounds, 3(9), 206–212. https://doi.org/10.52547/jcc.3.4.1

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