Ocular regenerative medicine using decellularized tissues en en Decellularization is the process of eliminating the cellular compartment of living tissues chemically or physically, resulting in an acellular extracellular matrix (ECM) scaffold that can be employed for a variety of reasons. Decellularized matrices are useful for tissue engineering applications because they preserve the tissue-specific mechanical, biochemical, and structural microenvironments while facilitating cellular engraftment and activities in the matrix. A variety of tissues have been decellularized by a variety of mechanical, chemical, and enzyme-based techniques and used to create bio scaffolds for diverse cell types such as primary cells, progenitor cells, and stem cells. Various applications and approaches are used in ocular tissue engineering and regeneration. Repairing the damaged structure in the corneal epithelium or the retinal ganglion cells is one of them. Scaffolds of biocompatible, biodegradable, natural, or synthetic polymers may be used in such applications. Stem cells can also be used to replicate vital cells in order to maintain vision function. Decellularized matrices can be used to create scaffolds for ocular tissue engineering, artificial arteries, cell culture matrices, and transplantation carriers, among other things. To gain a better understanding of regenerative medicine, we'll look at different types of decellularized tissue matrices and how they've been used to create artificial organs and regenerate injured tissues. 97 108 Ajeesh Chandrasekharan Department of Biomaterials Science Pusan National University Republic of Korea info@jourcc.com Erfan Yazdani Department of Medicine North Khorasan University of Medical Sciences Iran info@jourcc.com Aida Mahdian Faculty of Medicine Kashan University of Medical Science Iran info@jourcc.com Seyed AmirAbbas Shahidi Marnani Faculty of Medical Sciences University of Isfahan Iran info@jourcc.com Shadi Askari Department of Biomedical Engineering Amirkabir University of Technology Iran mapa4753@aut.ac.ir Decellularized tissue Ocular regeneration Decellularization methods Cornea Retina Article5.pdf [1] C. Mason, P. Dunnill, A brief definition of regenerative medicine, (2008). ## [2] K. Uematsu, K. Hattori, Y. Ishimoto, J. Yamauchi, T. Habata, Y. Takakura, H. 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