Targeted drug delivery by bone cements en en Bone cement (BC) is one of the most crucial materials for the substitution of damaged bones. Polymer or ceramic can be used as cement materials. Systemic drug delivery to the bone is difficult since human bone has limited perfusion. BC can carry drugs directly to the bone without causing adverse effects on healthy tissues, so it is a good choice for targeted drug delivery. Growth factors in addition to anti-inflammatory, anticancer, analgesic, and antibiotic reagents are just a few of the medicinal chemicals that may be added into BC for various treatment techniques. Our goal in this review is to introduce diverse BCs, drug loading mechanisms in BCs, and ultimately their clinical applications in dental potentials, inflammation therapy, bone infection, treatment of osteoporosis, coating of implants, and cancer therapy. 59 73 Zahra Kheradmand Department of Agriculture Islamic Azad University Maragheh Branch Iran info@jourcc.com Maryam Rabiei Department of Obstetric and Gynecology Tehran University of Medical Sciences Iran info@jourcc.com Akram Noori Tahneh Department of Pharmaceutical Chemistry Islamic Azad University Pharmaceutical Science Branch Iran info@jourcc.com Elham Shirali School of Medicine Tehran University of Medical Sciences Iran info@jourcc.com Morteza Abedi Department of Medicine Science Bojnurd University Iran info@jourcc.com Bahareh Dashtipour Department of Chemistry Alzahra University Iran b.dashtipour@alzahra.ac.ir Elham Barati School of Medicine Shahid Beheshti University of Medical Sciences Iran info@jourcc.com Targeted delivery Bone cement Anti-infection Coating Cancer therapy Dental application Article7.pdf [1] H. 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