1 Nanodiamond-containing composites for tissue scaffolds and surgical implants: A review https://jourcc.com/index.php/jourcc/article/view/jcc246 10.29252/jcc.2.4.6 20.1001.1.26765837.2020.2.5.6.0 1 Due to promising properties such as low toxicity against different cell lines, being highly stable fuorescent without showing photobleaching, and good surface properties, nanodiamonds have gained ever-increasing attention for various biomedical applications including bioimaging and therapeutic applications. Various methods are used for the fabrication of nanostructured diamond, the commonly used of which is the denotation technique. Newer approaches are being practiced for the modifcation and functionalization of their surfaces by different biomolecules suitable for interaction with considered targets. In this review, the scope and recent advancement in the feld of nanodiamonds for biomedical applications particularly their application for nanocomposite scaffold and implants are discussed. 215 227 Yasamin Zamani Tehran Medical Sciences Branch, Islamic Azad University (IAU) Iran info@jourcc.com Ali Zareein Tabriz Branch, Islamic Azad University (IAU) Iran info@jourcc.com Leila Bazli Iran University of Science and Technology Iran info@jourcc.com Reyhaneh NasrAzadani Isfahan University of Medical Sciences Iran info@jourcc.com Babar Pasha Mahammod National Institute of Technology Warangal India info@jourcc.com Shima Nasibi Shiraz University Iran info@jourcc.com Amir Modarresi Chahardehi Universiti Sains Malaysia Malaysia amirmch@gmail.com Nanodiamonds Surface modification Biomedical application Nanocomposite scaffold Implants Article6.pdf [1] O. Shenderova, V. Zhirnov, D. Brenner, Solid State Mater, Sci 27(3/4) (2002) 227. ##[2] J. 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