1 Recent advances in cobalt-based alloy and nano bioactive glass composites: Synthesis, characterization, and biomedical applications 1 Cobalt-based alloys and bioactive glasses are known as biomaterials used for orthopedic and dental applications because of their mechanical and biological properties. Due to the acceptable mechanical strength, fatigue resistance, and corrosion stability of cobalt-based alloys in physiological environments, these metallic alloys are suitable for load-bearing implants. However, they have faced some limitations in osseointegration and biological performance because of their high elastic modulus, limited bioactivity, and concerns about metallic ion release in long-term use. In contrast, nano bioactive glasses (nBGs) have shown excellent bioactivity, osteogenic potential, angiogenesis and antibacterial responses through surface reactivity and controlled ion release, but their brittleness and low fracture toughness limited their load-bearing application. This review provides an overview of recent advances in cobalt-based alloy/nano bioactive glass composites as a multi-component system which is designed to overcome the limitations of single-phase systems. The structural, mechanical, and chemical properties of cobalt-based alloys and nBGs are discussed, followed by the synergistic effects achieved at the metal–glass interface. Several synthesis and compositional strategies, such as melt-derived, sol–gel processing, powder metallurgy, additive manufacturing and surface coating techniques have been explored. The in vitro biological performance of these composites, including cytocompatibility, osteogenic differentiation, angiogenic stimulation, and antimicrobial activity, is discuss in relation to their potential applications in orthopedic and dental implants. Finally, key challenges such as mechanical compatibility, long-term stability, cobalt-related regulatory concerns, and future research directions are outlined. 1 11 Christine Narumbe Jore Department of Dentistry, Tbilisi state medical university, Tbilisi Georgia christinejore1996@gmail.com Mahsa Mohammadpour Beneh Khalkhal Faculty of Dentistry, Volgograd state medical university, Volgograd Russia mahsamohammadpour99@gmail.com Parisa Izadi Nanotechnology Engineering, Sapienza university of Rome, Rome Italy Paisa.sp@gmail.com Cobalt-based alloys Bioactive glasses Multi-component system Bioactivity Mechanical properties Load-bearing applications [1] M.N. Rahaman, D.E. Day, B.S. Bal, Q. Fu, S.B. Jung, L.F. Bonewald, A.P. Tomsia, Bioactive glass in tissue engineering, Acta biomaterialia 7(6) (2011) 2355-2373.##[2] M.C. Garcia-Mendez, V.H. Urrutia-Baca, C.A. Cuao-Moreu, E. Lorenzo-Bonet, M. Alvarez-Vera, D.M. Ortiz-Martinez, M.A. de la Garza-Ramos, In vitro biocompatibility evaluation of a new Co-Cr-B alloy with potential biomedical application, Metals 11(8) (2021) 1267.##[3] L.L. Hench, The story of Bioglass®, Journal of materials science: materials in medicine 17(11) (2006) 967-978.##[4] A.F. Mavrogenis, P.J. Papagelopoulos, G.C. Babis, Osseointegration of cobalt-chrome alloy implants, Journal of long-term effects of medical implants 21(4) (2011).##[5] L.L. Hench, J. Wilson, Biocompatibility of silicates for medical use, Ciba Foundation Symposium 121‐Silicon Biochemistry: Silicon Biochemistry: Ciba Foundation Symposium 121, Wiley Online Library, 2007, pp. 231-253.##[6] M.R. Bafandeh, R. Gharahkhani, M.H. Fathi, Characterization of fabricated cobalt-based alloy/nano bioactive glass composites, Materials Science and Engineering: C 69 (2016) 692-699.##[7] V.P.S. Sidhu, R. Borges, M. Yusuf, S. Mahmoudi, S.F. Ghorbani, M. Hosseinikia, P. Salahshour, F. Sadeghi, M. Arefian, A comprehensive review of bioactive glass: synthesis, ion substitution, application, challenges, and future perspectives, Journal of Composites and Compounds 3(9) (2021) 247-261.##[8] Q. Fu, E. Saiz, M.N. Rahaman, A.P. Tomsia, Bioactive glass scaffolds for bone tissue engineering: state of the art and future perspectives, Materials Science and Engineering: C 31(7) (2011) 1245-1256.##[9] L. Wondraczek, E. Bouchbinder, A. Ehrlicher, J.C. Mauro, R. Sajzew, M.M. Smedskjaer, Advancing the Mechanical Performance of Glasses: Perspectives and Challenges, Advanced Materials 34(14) (2022) 2109029.##[10] Q. Wang, Y. Ren, M.B. Shahzad, W. Zhang, X. Pan, S. Zhang, D. Zhang, Design and characterization of a novel nickel-free cobalt-base alloy for intravascular stents, Materials Science and Engineering: C 77 (2017) 565-571.##[11] N. Sedighi-Pirsaraei, A. Tamimi, F. Sadeghi Khamaneh, S. Dadras-Jeddi, N. Javaheri, Boron in wound healing: a comprehensive investigation of its diverse mechanisms, Frontiers in bioengineering and biotechnology 12 (2024) 1475584.##[12] M.A. Alshehri, Application of Chemically and Physically Synthesized Metal Nanoparticles to Staphylococcus aureus, Journal of Pharmaceutical Research International 34(28A) (2022) 36-59.##[13] W. Gregorowicz, L. Pajchel, The role of cobalt ions in angiogenesis—a review, International Journal of Molecular Sciences 26(15) (2025) 7236.##[14] J. Li, C. Zhao, C. Liu, Z. Wang, Z. Ling, B. Lin, B. Tan, L. Zhou, Y. Chen, D. Liu, Cobalt-doped bioceramic scaffolds fabricated by 3D printing show enhanced osteogenic and angiogenic properties for bone repair, Biomedical engineering online 20(1) (2021) 70.##[15] M.A. Hernandez-Rodriguez, D.A. Laverde-Cataño, D. Lozano, G. Martinez-Cazares, Y. Bedolla-Gil, Influence of boron addition on the microstructure and the corrosion resistance of CoCrMo alloy, Metals 9(3) (2019) 307.##[16] W. Fu, S. Liu, J. Jiao, Z. Xie, X. Huang, Y. Lu, H. Liu, S. Hu, E. Zuo, N. Kou, Wear resistance and biocompatibility of Co-Cr dental alloys fabricated with CAST and SLM techniques, Materials 15(9) (2022) 3263.##[17] J. Wilson, Metallic biomaterials: State of the art and new challenges, Fundamental Biomaterials: Metals (2018) 1-33.##[18] G. Radenković, D. Petković, Metallic biomaterials, Biomaterials in Clinical Practice: Advances in Clinical Research and Medical Devices, Springer2017, pp. 183-224.##[19] M.C. Tanzi, S. Farè, G. Candiani, Foundations of biomaterials engineering, Academic Press2019.##[20] L.H. Antunes, C.R. de Lima, Cobalt-chromium alloys–properties and applications, (2018).##[21] T. Narushima, K. Ueda, Alfirano, Co-Cr alloys as effective metallic biomaterials, Advances in metallic biomaterials: tissues, materials and biological reactions, Springer2015, pp. 157-178.##[22] S. He, Z.F. Li, X. Liu, X.M. Liu, C. Zhang, J.S. Wang, Carbide Precipitation Behavior of High‐Alloy Steel During Solidification and Cooling Process, steel research international 95(8) (2024) 2400130.##[23] K. Ueki, K. Ueda, T. Narushima, Microstructure and Mechanical Properties of Heat-Treated Co-20Cr-15W-10Ni Alloy for Biomedical Application, Metallurgical and Materials Transactions A 47(6) (2016) 2773-2782.##[24] J.E. Zerwekh, M.J. Nicar, T. Shimizu, W.J. Stith, The effect of pulsed electromagnetic fields on the corrosion of a chromium-cobalt-nickel alloy orthopaedic implant, Biomaterials 7(4) (1986) 243-246.##[25] J. Schaffer, An examination of fatigue initiation mechanisms in thin 35Co-35Ni-20Cr-10Mo medical grade wires, Journal of ASTM International 5(7) (2008) JAI101567.##[26] Y.S. Al Jabbari, Physico-mechanical properties and prosthodontic applications of Co-Cr dental alloys: a review of the literature, The journal of advanced prosthodontics 6(2) (2014) 138.##[27] B.E. Nagay, J.M. Cordeiro, V.A.R. Barão, Alloy materials for biomedical applications, Alloy Materials and Their Allied Applications (2020) 159-189.##[28] C. Spicer, Chemistry of Inorganic Biomaterials, Royal Society of Chemistry2021.##[29] Z. Guo, X. Pang, Y. Yan, K. Gao, A.A. Volinsky, T.-Y. Zhang, CoCrMo alloy for orthopedic implant application enhanced corrosion and tribocorrosion properties by nitrogen ion implantation, Applied surface science 347 (2015) 23-34.##[30] H. Li, M. Wang, D. Lou, W. Xia, X. Fang, Microstructural features of biomedical cobalt–chromium–molybdenum (CoCrMo) alloy from powder bed fusion to aging heat treatment, Journal of Materials Science and Technology 45 (2020) 146-156.##[31] J. Kandasamy, S. Arulvel, P. Jeyapandiarajan, M. Murugan, R. Prayer Riju, Recent Trends and Future Prospects in Metallic Implants for Biomedical Applications, Challenges and Innovations in 3D Printed Bio-Organs and Their Materials, Springer2025, pp. 223-253.##[32] A. Bandyopadhyay, I. Mitra, S.B. Goodman, M. Kumar, S. Bose, Improving biocompatibility for next generation of metallic implants, Progress in materials science 133 (2023) 101053.##[33] A. Vaicelyte, C. Janssen, M. Le Borgne, B. Grosgogeat, Cobalt–Chromium dental alloys: Metal exposures, toxicological risks, CMR classification, and EU regulatory framework, Crystals 10(12) (2020) 1151.##[34] M.C. Lucchetti, G. Fratto, F. Valeriani, E. De Vittori, S. Giampaoli, P. Papetti, V.R. Spica, L. Manzon, Cobalt-chromium alloys in dentistry: An evaluation of metal ion release, The Journal of prosthetic dentistry 114(4) (2015) 602-608.##[35] S. Lopez-Esteban, E. Saiz, S. Fujino, T. Oku, K. Suganuma, A.P. Tomsia, Bioactive glass coatings for orthopedic metallic implants, Journal of the European Ceramic Society 23(15) (2003) 2921-2930.##[36] L.L. Hench, Genetic design of bioactive glass, Journal of the European Ceramic Society 29(7) (2009) 1257-1265.##[37] L.L. Hench, J.M. Polak, Third-generation biomedical materials, Science 295(5557) (2002) 1014-1017.##[38] N. Jafari, K. Mikeladze, Magnesium-doped 58S bioglass: synthesis, characterization, and biomedical applications, Journal of Composites and Compounds 7(22) (2025).##[39] L.L. Hench, R.J. Splinter, W. Allen, T. Greenlee, Bonding mechanisms at the interface of ceramic prosthetic materials, Journal of biomedical materials research 5(6) (1971) 117-141.##[40] Q. Hu, X. Chen, N. Zhao, Y. Li, Facile synthesis and in vitro bioactivity of monodispersed mesoporous bioactive glass sub-micron spheres, Materials Letters 106 (2013) 452-455.##[41] Q. Hu, W. Jiang, Y. Li, X. Chen, J. Liu, T. Chen, G. Miao, The effects of morphology on physicochemical properties, bioactivity and biocompatibility of micro-/nano-bioactive glasses, Advanced Powder Technology 29(8) (2018) 1812-1819.##[42] A. Sadeghian, M. Kharaziha, M. Khoroushi, Dentin extracellular matrix loaded bioactive glass/GelMA support rapid bone mineralization for potential pulp regeneration, International Journal of Biological Macromolecules 234 (2023) 123771.##[43] M.S. Shoushtari, D. Hoey, D.R.A. Biak, N. Abdullah, S. Kamarudin, H.S. Zainuddin, Sol–gel‑templated bioactive glass scaffold: a review, Research on Biomedical Engineering 40(1) (2024) 281-296.##[44] M. Mačković, A. Hoppe, R. Detsch, D. Mohn, W.J. Stark, E. Spiecker, A. Boccaccini, Bioactive glass (type 45S5) nanoparticles: in vitro reactivity on nanoscale and biocompatibility, Journal of Nanoparticle Research 14(7) (2012) 966.##[45] T. Mehrabi, A.S. Mesgar, Z. Mohammadi, Bioactive glasses: a promising therapeutic ion release strategy for enhancing wound healing, ACS biomaterials science and engineering 6(10) (2020) 5399-5430.##[46] J. Ajita, S. Saravanan, N. Selvamurugan, Effect of size of bioactive glass nanoparticles on mesenchymal stem cell proliferation for dental and orthopedic applications, Materials Science and Engineering: C 53 (2015) 142-149.##[47] W. Gong, Y. Dong, S. Wang, X. Gao, X. Chen, A novel nano-sized bioactive glass stimulates osteogenesis via the MAPK pathway, RSC advances 7(23) (2017) 13760-13767.##[48] F. Baino, M. Montazerian, E. Verné, Cobalt-doped bioactive glasses for biomedical applications: a review, Materials 16(14) (2023) 4994.##[49] A.K. Solanki, F.V. Lali, H. Autefage, S. Agarwal, A. Nommeots-Nomm, A.D. Metcalfe, M.M. Stevens, J.R. Jones, Bioactive glasses and electrospun composites that release cobalt to stimulate the HIF pathway for wound healing applications, Biomaterials research 25(1) (2021) 1.##[50] J.R. de Souza, C. Anselmi, L.M. Cardoso, L.T. Kito, A.H. dos Reis-Prado, P.H. de Oliveira, R. Dal-Fabbro, M. Rahimnejad, T.M. Campos, L.T. Cintra, Electrospun SilkMA/silicate-chlorinated cobalt-doped bioactive glass composite for bone regeneration, Journal of the Mechanical Behavior of Biomedical Materials 164 (2025) 106929.##[51] I. Izquierdo‐Barba, A.J. Salinas, M. Vallet‐Regí, Bioactive glasses: from macro to nano, International Journal of Applied Glass Science 4(2) (2013) 149-161.##[52] L.L. Hench, J.R. Jones, Bioactive glasses: frontiers and challenges, Frontiers in bioengineering and biotechnology 3 (2015) 194.##[53] G. Kaur, G. Pickrell, N. Sriranganathan, V. Kumar, D. Homa, Review and the state of the art: sol–gel and melt quenched bioactive glasses for tissue engineering, Journal of Biomedical Materials Research Part B: Applied Biomaterials 104(6) (2016) 1248-1275.##[54] F. Niazvand, J. Hosseinzadeh, P. Zahed, N. Azizabadi, Effect of SrO incorporation on the morphology of sol-gel derived 58S bioactive glass, Journal of Composites and Compounds 7(25) (2025).##[55] R. Li, A. Clark, L. Hench, An investigation of bioactive glass powders by sol‐gel processing, Journal of Applied Biomaterials 2(4) (1991) 231-239.##[56] A. El-Fiqi, H.-W. Kim, Sol-gel synthesis and characterization of novel cobalt ions-containing mesoporous bioactive glass nanospheres as hypoxia and ferroptosis-inducing nanotherapeutics, Journal of Non-Crystalline Solids 569 (2021) 120999.##[57] X. Yan, C. Yu, X. Zhou, J. Tang, D. Zhao, Highly ordered mesoporous bioactive glasses with superior in vitro bone-forming bioactivities, Angewandte Chemie-International Edition 43(44) (2004) 5980-5984.##[58] H. Danninger, R. Calderon, C. Gierl-Mayer, Powder metallurgy and sintered materials, Addit. Manuf 19(4) (2017) pp.##[59] Z. Oksiuta, J. Dabrowski, A. Olszyna, Co–Cr–Mo-based composite reinforced with bioactive glass, Journal of materials processing technology 209(2) (2009) 978-985.##[60] V. Pavkov, G. Bakić, V. Maksimović, S. Stopić, Synthesis and characterisation of metal–glass composite materials fabricated by liquid phase sintering, Materials 18(19) (2025) 4622.##[61] T. Talapaneni, V. Chaturvedi, Consolidation of Mechanically Alloyed Powders, Mechanically Alloyed Novel Materials: Processing, Applications, and Properties, Springer2024, pp. 111-169.##[62] W. Lin, C. Chen, Characteristics of thin surface layers of cobalt-based alloys deposited by laser cladding, Surface and Coatings Technology 200(14-15) (2006) 4557-4563.##[63] R. Comesaña, F. Quintero, F. Lusquiños, M. Pascual, M. Boutinguiza, A. Durán, J. Pou, Laser cladding of bioactive glass coatings, Acta biomaterialia 6(3) (2010) 953-961.##[64] P. Monson, W. Steen, Comparison of laser hardfacing with conventional processes, Surface Engineering 6(3) (1990) 185-193.##[65] A. Hirose, K.F. Kobayashi, Formation of hybrid clad layers by laser processing, ISIJ international 35(6) (1995) 757-763.##[66] R. Ciriminna, A. Fidalgo, V. Pandarus, F. Beland, L.M. Ilharco, M. Pagliaro, The sol–gel route to advanced silica-based materials and recent applications, Chemical reviews 113(8) (2013) 6592-6620.##[67] D. Wang, G.P. Bierwagen, Sol–gel coatings on metals for corrosion protection, Progress in organic coatings 64(4) (2009) 327-338.##[68] A. Zanurin, N. Johari, J. Alias, H.M. Ayu, N. Redzuan, S. Izman, Research progress of sol-gel ceramic coating: A review, Materials today: proceedings 48 (2022) 1849-1854.##[69] M. Montazerian, F. Baino, E. Fiume, C. Migneco, A. Alaghmandfard, O. Sedighi, A.V. DeCeanne, C.J. Wilkinson, J.C. Mauro, Glass-ceramics in dentistry: Fundamentals, technologies, experimental techniques, applications, and open issues, Progress in Materials Science 132 (2023) 101023.##[70] A.M. Coco, F.A. Campos, T. Martins, B.R. Barrioni, P.L. Gastelois, D.C. Soares, M. Houmard, A.R. Boccaccini, E.H. Nunes, Synthesis and evaluation of mesoporous cobalt-doped bioactive glass nanospheres loaded with curcumin, Ceramics International (2025).##[71] A.K. Khosrowshahi, A.B. Khoshfetrat, Y.B. Khosrowshahi, H. Maleki-Ghaleh, Cobalt content modulates characteristics and osteogenic properties of cobalt-containing hydroxyapatite in in-vitro milieu, Materials Today Communications 27 (2021) 102392.##[72] A. Hoppe, N.S. Güldal, A.R. Boccaccini, A review of the biological response to ionic dissolution products from bioactive glasses and glass-ceramics, Biomaterials 32(11) (2011) 2757-2774.##[73] P. Valerio, M.M. Pereira, A.M. Goes, M.F. Leite, The effect of ionic products from bioactive glass dissolution on osteoblast proliferation and collagen production, Biomaterials 25(15) (2004) 2941-2948.##[74] J. Jiménez-Holguín, D. Lozano, M. Saiz-Pardo, D. De Pablo, L. Ortega, S. Enciso, B. Fernández-Tomé, I. Díaz-Güemes, F.M. Sánchez-Margallo, M. Portolés, Osteogenic-angiogenic coupled response of cobalt-containing mesoporous bioactive glasses in vivo, Acta Biomaterialia 176 (2024) 445-457.##[75] C. Wu, J. Chang, A review of bioactive silicate ceramics, Biomedical materials 8(3) (2013) 032001.##[76] H. Mehta, G. Kaur, G.R. Chaudhary, N. Prabhakar, S. Kaul, N.K. Singhal, Evaluation of corrosion resistant, antimicrobial and cytocompatible behaviour of cobalt based metallosurfactants self-assembled monolayers on 316L stainless steel surface, Surface and Coatings Technology 444 (2022) 128657.##[77] C. Liang, N. Huang, Study on hemocompatibility and corrosion behavior of ion implanted TiNi shape memory alloy and Co‐based alloys, Journal of Biomedical Materials Research Part A: An Official Journal of The Society for Biomaterials, The Japanese Society for Biomaterials, and The Australian Society for Biomaterials and the Korean Society for Biomaterials 83(1) (2007) 235-240.##[78] N.O. Joy-anne, Y. Su, X. Lu, P.-H. Kuo, J. Du, D. Zhu, Bioactive glass coatings on metallic implants for biomedical applications, Bioactive materials 4 (2019) 261-270.##[79] P. Munyensanga, M. Bricha, K. El Mabrouk, Enhanced bioactivity and biocorrosion resistance of porous CoCrMo implants with high-silica glass coatings, Materials Today Communications 42 (2025) 111477.##[80] A. Braem, T. Mattheys, B. Neirinck, M. Čeh, S. Novak, J. Schrooten, O. Van der Biest, J. Vleugels, Bioactive glass–ceramic coated titanium implants prepared by electrophoretic deposition, Materials science and engineering: C 32(8) (2012) 2267-2273.##[81] I. Peter, M. Rosso, A. Toppi, I. Dan, B. Ghiban, Investigation on cobalt based alloy modified by titanium for dental applications, Archives of Materials Science and Engineering 61(2) (2013) 62-68.##[82] C.Y. Lung, M.M. Abdalla, C.H. Chu, I. Yin, S.-R. Got, J.P. Matinlinna, A multi-element-doped porous bioactive glass coating for implant applications, Materials 14(4) (2021) 961.##[83] Ş.M. Tüzemen, Y.B. Bozkurt, B. Atik, Y. Uzun, A. Çelik, Electrochemical Impedance Spectroscopy Analysis of 45S5 Bioglass Coating on After Oxidation of CoCrW Alloy, Türk Doğa ve Fen Dergisi (1) (2024) 82-86.##[84] F. Kermani, S. Mollazadeh Beidokhti, F. Baino, Z. Gholamzadeh-Virany, M. Mozafari, S. Kargozar, Strontium-and cobalt-doped multicomponent mesoporous bioactive glasses (MBGs) for potential use in bone tissue engineering applications, Materials 13(6) (2020) 1348.##[85] S. Wang, C. Yang, L. Ren, M. Shen, K. Yang, Study on antibacterial performance of Cu-bearing cobalt-based alloy, Materials Letters 129 (2014) 88-90.##[86] M. Ansari, Bone tissue regeneration: biology, strategies and interface studies, Progress in biomaterials 8(4) (2019) 223-237.##[87] S.S. Shendage, G. Kamble, R. Chavan, N.R. Jadav, R.-a. Doong, J.-Y. Chang, A.V. Ghule, Bioactive Glass for Bone Tissue Regeneration: Focusing on the Key Biological Properties, ACS Biomaterials Science and Engineering 12(1) (2025) 71-89.##[88] M.H. Monfared, S. Mohandesnezhad, M. Azami, S. Samani, Robocast Zn-and Co-doped bioactive glass/tricalcium phosphate scaffolds for bone regeneration, Journal of Biological Engineering 20(1) (2026) 4.##[89] P. Ghiasi Tabari, A. Sattari, M. Mashhadi Keshtiban, N. Karkuki Osguei, J.G. Hardy, A. Samadikuchaksaraei, Injectable hydrogel scaffold incorporating microspheres containing cobalt‐doped bioactive glass for bone healing, Journal of Biomedical Materials Research Part A 112(12) (2024) 2225-2242.##[90] X. Zhang, K. Nan, Y. Zhang, K. Song, Z. Geng, D. Shang, L. Fan, Lithium and cobalt co-doped mesoporous bioactive glass nanoparticles promote osteogenesis and angiogenesis in bone regeneration, Frontiers in Bioengineering and Biotechnology 11 (2024) 1288393.##[91] Z. Deng, B. Lin, Z. Jiang, W. Huang, J. Li, X. Zeng, H. Wang, D. Wang, Y. Zhang, Hypoxia-mimicking cobalt-doped borosilicate bioactive glass scaffolds with enhanced angiogenic and osteogenic capacity for bone regeneration, International journal of biological sciences 15(6) (2019) 1113.##[92] V.R. dos Santos, T.M.B. Campos, C. Anselmi, G.P. Thim, M.C. Bottino, A.L.S. Borges, E. de Sousa Trichês, Effect of Co, Cu, and Zn ions on the bioactivity and antibacterial properties of a borate bioactive glass, Journal of Non-Crystalline Solids 622 (2023) 122643.##[93] E. Vafa, L. Tayebi, M. Abbasi, M.J. Azizli, R. Bazargan-Lari, A. Talaiekhozani, Z. Zareshahrabadi, A. Vaez, A.M. Amani, H. Kamyab, A better roadmap for designing novel bioactive glasses: effective approaches for the development of innovative revolutionary bioglasses for future biomedical applications, Environmental Science and Pollution Research 30(55) (2023) 116960-116983.##[94] L. Wang, J. Kang, C. Sun, D. Li, Y. Cao, Z. Jin, Mapping porous microstructures to yield desired mechanical properties for application in 3D printed bone scaffolds and orthopaedic implants, Materials and Design 133 (2017) 62-68.##[95] K. Chen, X.-k. He, Z.-d. Liu, Y. Zheng, J. Ma, Effect of cooling rate on dendritic segregation and solidification structure of a Ni–Cr–Co–Mo based alloy, Journal of Iron and Steel Research International 32(10) (2025) 3555-3572.##[96] A.C. Marsh, N.P. Mellott, N. Pajares-Chamorro, M. Crimp, A. Wren, N.D. Hammer, X. Chatzistavrou, Fabrication and multiscale characterization of 3D silver containing bioactive glass-ceramic scaffolds, Bioactive Materials 4 (2019) 215-223.##[97] R. Fan, E. Guo, L. Wang, L. Wang, S. Zhao, X. Li, X. Zhang, B. Cui, Multi-scale microstructure strengthening strategy in CoCrFeNiNb0. 1Mo0. 3 high entropy alloy overcoming strength-ductility trade-off, Materials Science and Engineering: A 882 (2023) 145446.##[98] J. Jones, L. Hench, Biomedical materials for new millennium: perspective on the future, Materials Science and technology 17(8) (2001) 891-900.##[99] A.-L. Mîrț, D. Ficai, O.-C. Oprea, G. Vasilievici, A. Ficai, Current and future perspectives of bioactive glasses as injectable material, Nanomaterials 14(14) (2024) 1196.