1 Influence of Ionic Size on the concentration of Ag+ and Zn2+ in Simulated Body Fluid: Modeling and Monte Carlo Simulation with Dental Applications 1 The influences of silver (Ag+) and zinc (Zn2+) ions, and their proposed action on bioactive glass for dental applications, are investigated through computational modeling and Monte Carlo simulation. Bioactive glass materials will continue to be adopted as dental restorative materials, pulp-capping agents, and implant coatings because they can provide a potentially therapeutic way to deliver ions that may possess antimicrobial properties and help stimulate tissue regeneration. Profiles of Ag⁺ and Zn²⁺ as a function of time in simulated body fluid were simulated to compare and contrast their release behavior. Zn²⁺, having a smaller ionic radius, may be released more efficiently than Ag⁺ making Zn²⁺ has a greater release potential while Ag⁺ may release more slowly, and some may have been retained even in the bioactive glass structure. Monte Carlo simulations allows for best assessment of the stochastic nature of ion transport that enabled the visualisation of release potential and release efficiencies in chronological blocks of information. The findings indicate how important it will be to consider ionic size, transport mechanisms, and release potential when designing bioactive glass. If bioactive glass or bioactive materials can be designed with a target of delivery and duration of release it may be feasible to use Zn²⁺ or Ag⁺ to facilitate remineralisation, support pulpal healing and long-term antibacterial protection in dental applications while also fostering the advancement of controlled programmable bioactive dental materials. 1 6 Masoumeh Khamehchi Department of Basic Science, Hamedan University of Technology, Hamedan, 65169-1-3733 Iran mkhamehchi@gmail.com Ana Chkhenkeli BAU International University, Batumi School of Medicine and Health Science Georgia anukachx@gmail.com Bioactivity Modeling Monte Carlo simulation Ion concentration Dental application Article5.pdf [1] F. Baino, G. Novajra, V. Miguez-Pacheco, A.R. Boccaccini, C. Vitale-Brovarone, Bioactive glasses: Special applications outside the skeletal system, Journal of Non-Crystalline Solids 432 (2016) 15-30.##[2] Z. Ahmadi, F. 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