1 Advancements in Nanostructured Drug Delivery Systems: A Commentary on Multifunctional Approaches for Cancer and Inflammatory Disease Treatment 1 Nanostructured drug delivery systems (NDDS) represent a transformative advancement in medical science, offering innovative solutions for the treatment of cancer and inflammatory diseases. These systems utilize nanoscale materials to enhance the efficacy and specificity of drug delivery, allowing for targeted therapy that minimizes side effects. By improving the bioavailability of therapeutic agents, NDDS can significantly increase treatment effectiveness. Furthermore, their ability to navigate biological barriers opens new avenues for overcoming challenges in conventional drug delivery methods 210 211 Jaleh Varshosaz Novel Drug Delivery Systems Research Center, Department of Pharmaceutics, School of Pharmacy and Pharmaceutical Sciences, Isfahan University of Medical Sciences Iran varshosaz@pharm.mui.ac.ir Nanostructure Drug Delivery Systems Cancer treatment Inflammatory Disease Article7.pdf [1] M. Qasim, D.-J. Lim, H. Park, D. Na, Nanotechnology for diagnosis and treatment of infectious diseases, Journal of nanoscience and nanotechnology 14(10) (2014) 7374-7387.##[2] P.V. Teixeira, E. Fernandes, T.B. Soares, F. Adega, C.M. Lopes, M. Lúcio, Natural Compounds: Co-Delivery Strategies with Chemotherapeutic Agents or Nucleic Acids Using Lipid-Based Nanocarriers, Pharmaceutics, 2023.##[3] J. Majumder, O. Taratula, T. Minko, Nanocarrier-based systems for targeted and site specific therapeutic delivery, Adv Drug Deliv Rev 144 (2019) 57-77 .##[4] T. Sahu, Y.K. Ratre, S. Chauhan, L.V.K.S. Bhaskar, M.P. Nair, H.K. Verma, Nanotechnology based drug delivery system: Current strategies and emerging therapeutic potential for medical science, Journal of Drug Delivery Science and Technology 63 (2021) 102487 .##[5] A. Simonazzi, A.G. Cid, M. Villegas, A.I. Romero, S.D. Palma, J.M. Bermúdez, Chapter 3 -Nanotechnology applications in drug controlled release, in: A.M. Grumezescu (Ed.), Drug Targeting and Stimuli Sensitive Drug Delivery Systems, William Andrew Publishing2018, pp. 81-116.##[6] R. Augustine, A. Hasan, R. Primavera, R.J. Wilson, A.S. Thakor, B.D. Kevadiya, Cellular uptake and retention of nanoparticles: Insights on particle properties and interaction with cellular components, Materials Today Communications 25 (2020) 101692 .##[7] J. Huang, Y. Li, A. Orza, Q. Lu, P. Guo, L. Wang, L. Yang, H. Mao, Magnetic Nanoparticle Facilitated Drug Delivery for Cancer Therapy with Targeted and Image-Guided Approaches, Advanced Functional Materials 26(22) (2016) 3818-3836 .##[8] A. Hemmat, E. Ghassami, M. Minaiyan, J. Varshosaz, Magnetophoretic Intranasal Drug-loaded Magnetic Nano-aggregates as a Platform for Drug Delivery in Status Epilepticus, Pharm Nanotechnol 11(2) (2023) 155-166 .##[9] A. Jash, A. Ubeyitogullari, S.S.H. Rizvi, Liposomes for oral delivery of protein and peptide-based therapeutics: challenges, formulation strategies, and advances, Journal of Materials Chemistry B 9(24) (2021) 4773-4792 .##[10] Q. Jiang, S. Liu, J. Liu, Z.-G. Wang, B. Ding, Rationally Designed DNA-Origami Nanomaterials for Drug Delivery In Vivo, Advanced Materials 31(45) (2019) 1804785 .##[11] E.M.D. San Valentin, A.J.R. Barcena, C. Klusman, B. Martin, M.P. Melancon, Nano-embedded medical devices and delivery systems in interventional radiology, WIREs Nanomedicine and Nanobiotechnology 15(1) (2023) e1841 .##[12] O. Adir, M. Poley, G. Chen, S. Froim, N. Krinsky, J. Shklover, J. Shainsky-Roitman, T. Lammers, A. Schroeder, Integrating Artificial Intelligence and Nanotechnology for Precision Cancer Medicine, Advanced Materials 32(13) (2020) 1901989 .##[13] E. Güven, Nanotechnology-based drug delivery systems in orthopedics, Jt Dis Relat Surg 32(1) (2021) 267-273 .##[14] C. Huang, Q. You, J. Xu, D. Wu, H. Chen, Y. Guo, J. Xu, M. Hu, H. Qian, An mTOR siRNA-Loaded Spermidine/DNA Tetrahedron Nanoplatform with a Synergistic Anti-Inflammatory Effect on Acute Lung Injury, Advanced Healthcare Materials 11(11) (2022) 2200008.##[15] D. Prosperi, M. Colombo, I. Zanoni, F. Granucci, Drug nanocarriers to treat autoimmunity and chronic inflammatory diseases, Semin Immunol 34 (2017) 61-67 .