10.61186/jcc.5.4.3 1 Smart biomaterial composites for controlled drug release: mechanisms and applications 1 Smart biomaterial composites signify an important progress for biomedical engineering, particularly in the area of measuring drug release. These innovative materials are engineered to respond to specific stimuli from their environment, enabling precise andtargeted delivery of therapeutic compounds. The integration of smart biomaterials into medication systems is key to enhancing treatment efficacy and safety, as they can diminish side effects and improve patient adherence by maintaining drug levels within the therapeutic window. The aim of this article is to explore the mechanisms and applications of smart biomaterial composites in controlled drug release, highlighting their potential to revolutionize therapeutic strategies in biomedical engineering. 1 6 Amaneh Bakhtiari Department of Biology, Shahid Chamran University Iran info@jourcc.com Lili Arabuli Department of Natural Sciences, School of Science and Technology, University of Georgia Yildiz Technical University, Science and Art Faculty, Davutpasa Campus, 34220, Esenler Georgia Türkiye l.arabuli@ug.edu.ge Farnaz Sadeghi Department of Biomedical Engineering, Islamic Azad University, Central Tehran Branch Iran info@jourcc.com Drug Release Smart Biomaterial Composites Release Kinetics Article3.pdf [1] R.A. Perez, J.-E. Won, J.C. Knowles, H.-W. Kim, Naturally and synthetic smart composite biomaterials for tissue regeneration, Advanced drug delivery reviews 65(4) (2013) 471-496.##[2] S.S. Das, P. Bharadwaj, M. Bilal, M. Barani, A. Rahdar, P. Taboada, S. 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