1 Review of samarium‐containing bioactive glasses: biomedical applications 1 Samarium, a rare earth element, has attracted considerable attention in biomaterials due to its distinct physicochemical properties and possible bioactivity. This review focuses on samarium-containing bioactive glasses, highlighting their composition and the role of samarium in enhancing bioactivity, biocompatibility, and antibacterial properties. The incorporation of samarium ions has been shown to influence the structural characteristics of bioactive glasses, promoting superior interaction with biological tissues and improved osteogenic activity. Incorporating samarium into bioactive glasses (BGs) enhances their bioactivity and mechanical strength. Various biomedical applications, including bone regeneration, drug delivery systems, and tissue engineering, are explored, showcasing the versatility and effectiveness of these materials in medical settings. A comprehensive analysis of recent literature reveals ongoing advancements in the properties and application of samarium-containing bioactive glasses, paving the way for future research and clinical applications in regenerative medicine. 1 8 Negin Khosravi School of Scienceand Health, The University of Georgia Georgia info@jourcc.com Aramis Moradi Zand Institute of HigherEducation Iran info@jourcc.com Fariborz Sharifianjazi Center for Advanced Materials and Structures, School of Science and Technology, The University of Georgia Georgia f.sharifianjazi@ug.edu.ge Ketevan Tavamaishvili School of Medicine, Georgian American University, 10 Merab Aleksidze Street Georgia info@jourcc.com Ameneh Bakhtiari Department of Biology, Shahid Chamran University Iran info@jourcc.com Ali Mohammadi Department of Chemistry, Faculty of Science, University of Zanjan Iran info@jourcc.com Samarium Bioactive glasses Physical and biological properties Biomedical applications Article3.pdf [1] G. Kaur, O.P. 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