Effect of MgF2 addition on the mechanical properties of hydroxyapatite synthesized via powder metallurgy
DOI:
https://doi.org/10.29252/jcc.1.1.3Keywords:
Hydroxyapatite, Magnesium Fluoride (MgF2), Tri-Calcium Phosphate (TCP), SinterAbstract
Hydroxyapatite, a type of bioceramics, is mainly used as an implant for hard tissues due to its similarity to the structure of hard tissues. The aim of this study is to improve the mechanical properties of hydroxyapatite for biological uses. For this purpose the effect of magnesium fluoride (MgF2) addition with different weight percentages (0, 5, 7.5 and 10 wt. %) on the mechanical properties of pure hydroxyapatite sintered at various temperatures (900, 1000 and 1100 °C) was investigated. XRD analysis was performed to study the decomposition of hydroxyapatite and the transformed phases. The density, Vickers microhardness and fracture toughness of the specimens were measured. The SEM analysis was performed to investigate the microstructure of samples. The results showed that the decomposition of hydroxyapatite to tri-calcium phosphate (TCP) decreased with increasing MgF2. Also, an increment in density and mechanical properties of the specimens were observed with increasing the amount of hydroxyapatite. The fracture toughness of sintered pure hydroxyapatite increased from 2.3 to 1.3 MPa.m1/2. The specimen containing 10 wt. % MgF2 sintered at 1100 °C showed the best mechanical properties.
References
A. Esmaeilkhanian, F. Sharifianjazi, A. Abouchenari, A. Rouhani, N. Parvin, M. Irani, Synthesis and Characterization of Natural Nano-hydroxyapatite Derived from Turkey Femur-Bone Waste, Applied Biochemistry and Biotechnology 189(3) (2019) 919-932.
N.A.S. Mohd Pu’ad, P. Koshy, H.Z. Abdullah, M.I. Idris, T.C. Lee, Syntheses of hydroxyapatite from natural sources, Heliyon 5(5) (2019) e01588.
S.K. Hubadillah, M.H.D. Othman, Z.S. Tai, M.R. Jamalludin, N.K. Yusuf, A. Ahmad, M.A. Rahman, J. Jaafar, S.H.S.A. Kadir, Z. Harun, Novel hydroxyapa-tite-based bio-ceramic hollow fiber membrane derived from waste cow bone for textile wastewater treatment, Chemical Engineering Journal 379 (2020) 122396.
F. Sharifianjazi, N. Parvin, M. Tahriri, Formation of apatite nano-needles on novel gel derived SiO2-P2O5-CaO-SrO-Ag2O bioactive glasses, Ceramics Interna-tional 43(17) (2017) 15214-15220.
E. Sharifi Sedeh, S. Mirdamadi, F. Sharifianjazi, M. Tahriri, Synthesis and evaluation of mechanical and biological properties of scaffold prepared from Ti and Mg with different volume percent, Synthesis and Reactivity in Inorganic, Met-al-Organic, and Nano-Metal Chemistry 45(7) (2015) 1087-1091.
A. Moghanian, A. Ghorbanoghli, M. Kazem-Rostami, A. Pazhouheshgar, E. Salari, M. Saghafi Yazdi, T. Alimardani, H. Jahani, F. Sharifian Jazi, M. Tahriri, Novel antibacterial Cu/Mg-substituted 58S-bioglass: Synthesis, characterization and investigation of in vitro bioactivity, International Journal of Applied Glass Science 11(4) (2020) 685-698.
B.Y.S. Kumar, A.M. Isloor, G.C.M. Kumar, Inamuddin, A.M. Asiri, Nanohy-droxyapatite Reinforced Chitosan Composite Hydrogel with Tunable Mechani-cal and Biological Properties for Cartilage Regeneration, Scientific Reports 9(1) (2019) 15957.
C.C. Coelho, L. Grenho, P.S. Gomes, P.A. Quadros, M.H. Fernandes, Nano-hydroxyapatite in oral care cosmetics: characterization and cytotoxicity assessment, Scientific Reports 9(1) (2019) 11050.
Z. Evis, R.H. Doremus, Effect of AlF3, CaF2 and MgF2 on hot-pressed hydroxy-apatite–nanophase alpha-alumina composites, Materials Research Bulletin 43(10) (2008) 2643-2651.
Z. Evis, M. Usta, I. Kutbay, Hydroxyapatite and zirconia composites: Effect of MgO and MgF2 on the stability of phases and sinterability, Materials Chemistry and Physics 110(1) (2008) 68-75.
M. Fanovich, M. Castro, J.P. Lopez, Improvement of the microstructure and microhardness of hydroxyapatite ceramics by addition of lithium, Materials Let-ters 33(5-6) (1998) 269-272.
D.S. Gomes, A.M.C. Santos, G.A. Neves, R.R. Menezes, A brief review on hydroxyapatite production and use in biomedicine, Cerâmica 65 (2019) 282-302.
S.-J. Kim, H.-G. Bang, J.-H. Song, S.-Y. Park, Effect of fluoride additive on the mechanical properties of hydroxyapatite/alumina composites, Ceramics Inter-national 35(4) (2009) 1647-1650.
Y. Shinno, T. Ishimoto, M. Saito, R. Uemura, M. Arino, K. Marumo, T. Na-kano, M. Hayashi, Comprehensive analyses of how tubule occlusion and advanced glycation end-products diminish strength of aged dentin, Scientific Reports 6(1) (2016) 19849.
P. Abasian, M. Radmansouri, M. Habibi Jouybari, M.V. Ghasemi, A. Moham-madi, M. Irani, F.S. Jazi, Incorporation of magnetic NaX zeolite/DOX into the PLA/chitosan nanofibers for sustained release of doxorubicin against carcinoma cells death in vitro, International Journal of Biological Macromolecules 121 (2019) 398-406.
M.M. Aliasghar Abuchenari, The Effect of Cu-Substitution on the Microstruc-ture and Magnetic Properties of Fe-15%Ni alloy Prepared by Mechanical Alloying composites and compounds 1(1) (2019) 13-19.
M. Ekrami, J. Shahbazi Karami, A. Araee, F. Sharifianjazi, E. Sadeghi, A. Moghanian, Fabrication of copper/stainless steel bimetallic couple, by diffusion bonding using silver and nickel foils as interlayers, Inorganic and Nano-Metal Chemistry 49(5) (2019) 152-162.
Z. Goudarzi, N. Parvin, F. Sharifianjazi, Formation of hydroxyapatite on sur-face of SiO2– P2O5–CaO–SrO–ZnO bioactive glass synthesized through sol-gel route, Ceramics International 45(15) (2019) 19323-19330.
M.S. Leila Bazli, Arman Shiravi, A Review of Carbon Nanotube/TiO2 Com-posite Prepared via Sol-Gel Method compsites and compounds 1(1) (2019) 1-12.
A. Moghanian, F. Sharifianjazi, P. Abachi, E. Sadeghi, H. Jafarikhorami, A. Sedghi, Production and properties of Cu/TiO2 nano-composites, Journal of Alloys and Compounds 698 (2017) 518-524.
M. Radmansouri, E. Bahmani, E. Sarikhani, K. Rahmani, F. Sharifianjazi, M. Irani, Doxorubicin hydrochloride - Loaded electrospun chitosan/cobalt ferrite/tita-nium oxide nanofibers for hyperthermic tumor cell treatment and controlled drug release, International Journal of Biological Macromolecules 116 (2018) 378-384.
V. Salimian Rizi, F. Sharifianjazi, H. Jafarikhorami, N. Parvin, L. Saei Fard, M. Irani, A. Esmaeilkhanian, Sol–gel derived SnO2/Ag2O ceramic nanocomposite for H2 gas sensing applications, Materials Research Express 6(11) (2019) 1150g2.
M.S.N. Shahrbabak, F. Sharifianjazi, D. Rahban, A. Salimi, A Comparative Investigation on Bioactivity and Antibacterial Properties of Sol-Gel Derived 58S Bioactive Glass Substituted by Ag and Zn, Silicon 11(6) (2019) 2741-2751.
F. Sharifianjazi, N. Parvin, M. Tahriri, Synthesis and characteristics of sol-gel bioactive SiO2-P2O5-CaO-Ag2O glasses, Journal of Non-Crystalline Solids 476 (2017) 108-113.
Z. Evis, M. Usta, I. Kutbay, Improvement in sinterability and phase stability of hydroxyapatite and partially stabilized zirconia composites, Journal of the Eu-ropean Ceramic Society 29(4) (2009) 621-628.
Y. Luo, D. Li, J. Zhao, Z. Yang, P. Kang, In vivo evaluation of porous lithi-um-doped hydroxyapatite scaffolds for the treatment of bone defect, Bio-medical materials and engineering (Preprint) (2018) 1-23.
K. Hua, X. Xi, L. Xu, K. Zhao, J. Wu, A. Shui, Effects of AlF3 and MoO3 on properties of Mullite whisker reinforced porous ceramics fabricated from construc-tion waste, Ceramics International 42(15) (2016) 17179-17184.
S.S. Rahavi, O. Ghaderi, A. Monshi, M.H. Fathi, A comparative study on physicochemical properties of hydroxyapatite powders derived from natural and synthetic sources, Russian Journal of Non-Ferrous Metals 58(3) (2017) 276-286.
K. Kowalski, M.U. Jurczyk, P.K. Wirstlein, J. Jakubowicz, M. Jurczyk, Prop-erties of ultrafine-grained Mg-based composites modified by addition of silver and hydroxyapatite, Materials Science and Technology 34(9) (2018) 1096-1103.
H.X. Chen, F. Xue, D. Yang, Y.Z. Qiufen, Hydrothermal synthesis and char-acterization of Ag-doped hydroxyapatite antibacterial agent, Acta Chimica Sinica 70(12) (2012) 1362-1366.
H.-W. Kim, Y.-H. Koh, S.-B. Seo, H.-E. Kim, Properties of fluoridated hy-droxyapatite–alumina biological composites densified with addition of CaF2, Ma-terials Science and Engineering: C 23(4) (2003) 515-521.
I. Manjubala, T. Sampath Kumar, Preparation of biphasic calcium phosphate doped with magnesium fluoride for osteoporotic applications, Journal of materials science letters 20(13) (2001) 1225-1227.
M. Turkoz, A.O. Atilla, Z. Evis, Silver and fluoride doped hydroxyapatites: investigation by microstructure, mechanical and antibacterial properties, Ceramics International 39(8) (2013) 8925-8931.
C.-C. Wu, S.-T. Huang, T.-W. Tseng, Q.-L. Rao, H.-C. Lin, FT-IR and XRD investigations on sintered fluoridated hydroxyapatite composites, Journal of Mo-lecular Structure 979(1-3) (2010) 72-76.
B. Bakhshandeh, M. Soleimani, N. Ghaemi, I. Shabani, Effective combination of aligned nanocomposite nanofibers and human unrestricted somatic stem cells for bone tissue engineering, Acta Pharmacologica Sinica 32(5) (2011) 626-636.
E. Nogami, I. Watanabe, H. Hoshi, M. Kasahara, N. Honda, M. Sato, K. Suzu-ki, D-sorbitol can keep the viscosity of dispersive ophthalmic viscosurgical device at room temperature for long term, Scientific Reports 9(1) (2019) 16815.
M. Ibrahim, M. Labaki, J.-M. Giraudon, J.-F. Lamonier, Hydroxyapatite, a multifunctional material for air, water and soil pollution control: A review, Journal of Hazardous Materials 383 (2020) 121139.
D.O. Obada, E.T. Dauda, J.K. Abifarin, D. Dodoo-Arhin, N.D. Bansod, Me-chanical properties of natural hydroxyapatite using low cold compaction pressure: Effect of sintering temperature, Materials Chemistry and Physics 239 (2020) 122099.
X. Li, J. Zhu, Z. Man, Y. Ao, H. Chen, Investigation on the structure and upconversion fluorescence of Yb3+/Ho3+ co-doped fluorapatite crystals for potential biomedical applications, Scientific Reports 4(1) (2014) 4446.
E.H. Jazi, R. Esalmi-Farsani, G. Borhani, F.S. Jazi, Synthesis and Character-ization of In Situ Al-Al13Fe4-Al2O3-TiB2 Nanocomposite Powder by Mechanical Alloying and Subsequent Heat Treatment, Synthesis and Reactivity in Inorganic, Metal-Organic, and Nano-Metal Chemistry 44(2) (2014) 177-184.
A. Masoudian, M. Karbasi, F. SharifianJazi, A. Saidi, Developing Al2O3-TiC in-situ nanocomposite by SHS and analyzingtheeffects of Al content and mechan-ical activation on microstructure, Journal of Ceramic Processing Research 14(4) (2013) 486-491.
C. Kursun, M. Gogebakan, E. Uludag, M.S. Bozgeyik, F.S. Uludag, Struc-tural, electrical and magnetic properties of Nd – A – CoO3 (A = Sr, Ca) Perovskite Powders by Mechanical Alloying, Scientific Reports 8(1) (2018) 13083.
M.S. Mustaffa, R.a.S. Azis, N.H. Abdullah, I. Ismail, I.R. Ibrahim, An investi-gation of microstructural, magnetic and microwave absorption properties of multi-walled carbon nanotubes/Ni0.5Zn0.5Fe2O4, Scientific Reports 9(1) (2019) 15523.
Y.-J. Hu, J. Li, K.A. Darling, W.Y. Wang, B.K. VanLeeuwen, X.L. Liu, L.J. Kecskes, E.C. Dickey, Z.-K. Liu, Nano-sized Superlattice Clusters Created by Ox-ygen Ordering in Mechanically Alloyed Fe Alloys, Scientific Reports 5(1) (2015) 11772.
Asfandiyar, T.-R. Wei, Z. Li, F.-H. Sun, Y. Pan, C.-F. Wu, M.U. Farooq, H. Tang, F. Li, B. Li, J.-F. Li, Thermoelectric SnS and SnS-SnSe solid solutions pre-pared by mechanical alloying and spark plasma sintering: Anisotropic thermoelec-tric properties, Scientific Reports 7(1) (2017) 43262.
V. Balouchi, F.S. Jazi, A. Saidi, Developing (W, Ti) C-(Ni, Co) nanocomposite by SHS method, Journal of Ceramic Processing Research 16(5) (2015) 605-608.
M. Alizadeh, F. Sharifianjazi, E. Haghshenasjazi, M. Aghakhani, L. Rajabi, Production of nanosized boron oxide powder by high-energy ball milling, Synthe-sis and Reactivity in Inorganic, Metal-Organic, and Nano-Metal Chemistry 45(1) (2015) 11-14.
J.J. Kruzic, D.K. Kim, K.J. Koester, R.O. Ritchie, Indentation techniques for evaluating the fracture toughness of biomaterials and hard tissues, Journal of the Mechanical Behavior of Biomedical Materials 2(4) (2009) 384-395.
H.-W. Kim, Y.-J. Noh, Y.-H. Koh, H.-E. Kim, H.-M. Kim, Effect of CaF2 on densification and properties of hydroxyapatite–zirconia composites for biomedical applications, Biomaterials 23(20) (2002) 4113-4121.
A.R. Rouhani, A.H. Esmaeil-Khanian, F. Davar, S. Hasani, The effect of agarose content on the morphology, phase evolution, and magnetic properties of CoFe2O4 nanoparticles prepared by sol-gel autocombustion method, International Journal of Applied Ceramic Technology 15(3) (2018) 758-765.
H. Ibrahim, S.N. Esfahani, B. Poorganji, D. Dean, M. Elahinia, Resorbable bone fixation alloys, forming, and post-fabrication treatments, Materials Science and Engineering: C 70 (2017) 870-888.
I. Mutlu, Production and fluoride treatment of Mg-Ca-Zn-Co alloy foam for tissue engineering applications, Transactions of Nonferrous Metals Society of Chi-na 28(1) (2018) 114-124.
Article DOR: 20.1001.1.26765837.2019.1.1.3.2
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